Oncoblot A test for the ENOX 2 protein. Only cancer cells have the ENOX 2 protein.  It’s about $850.  If they find the ENOX 2 protein, they can tell which of the 27 major types of cancer you have. They cannot tell the location of the cancer, only the origination point. Contact: Rebecca Davis Phone: 972-510-7773

SOURCE: www.oncoblotlabs.com or e-mail info@oncoblotlabs.com

 

RGCC Oncocount  – From your blood, they can identify circulating tumor cells

 

Nagalase Level A blood test that runs about $90.  A nagalase is an enzyme that’s put out by cancer cells and by viruses.  It’s proportional to tumor burden .  So a simple blood test… you go in for a physical, you get a CBC and blood sugar and cholesterol… get a nagalase test …. source of above 3: https://www.ihealthtube.com/video/these-tests-detect-cancer-earlier-why-arent-they-more-common

 

3 Tesla MRI-scanner (Siemens Magnetom Skyra 3T)  https://drive.google.com/file/d/0By0PxetKDZvMVU5FZUx4c041c21PeV9PeGd2VEVlVUdOM24w/view

Radboud University Nijmegen, Medical Centre, Netherlands

“The current gold standard MRI is the 3 Tesla version with contrast dye and PIRADS 2 software”   SOURCE: https://www.inspire.com/groups/us-too-prostate-cancer/discussion/4k-test-result-what-next/?reply_sort=asc#replies

IsoPSA Improves Detection of Clinically Important Cancers

Interim analysis of new prostate cancer test is promising.

SOURCE: https://consultqd.clevelandclinic.org/2016/05/isopsa-improves-detection-clinically-important-cancers/

 

Here are comments from Ara Karamanian, MD:

1. 3T MRI: This describes the magnetic strength of the MRI machine. In the vast majority of cases, 3T is the best for prostate imaging. This is available in many centers across the country.
2. Multiparametric MRI or mpMRI: This is a combination of different MRI sequences that is used to perform excellent imaging of the prostate, especially when performed with a 3T MRI. This is available in many centers across the country.
3. The laser system that is used is called Visualase, and there are only a few practitioners who perform MRI guided focal laser ablation in the prostate. The laser is part of the computer system, a fiber optic plugs into the laser on one end, and goes into the patient on the other end. There are two different types of fibers. One is 0.4 mm in diameter, has a 10 mm diffusion tip and is wrapped in blue plastic. The other is 0.6 mm in diameter, has a 15 mm diffusion tip, and is wrapped in orange plastic. The color of the plastic isn’t important, the characteristics of the fiber itself are important. What we’ve found is that by using the “orange” laser, which creates a larger ablation zone, there is a lower risk of recurrence because it takes wider margins.
The technology is very elegant. Combining MRI guidance for targeting and temperature monitoring with a precision laser results in very predictable and precise ablation zones. This translates into quick recovery and very little side effects for most patients.
Hope this helps clarify.
Best regards,
Ara Karamanian, MD

SOURCE: https://www.inspire.com/groups/us-too-prostate-cancer/discussion/what-does-the-terminology-bluelaser-mean/

PCA3 Test –

SOURCE: https://www.youtube.com/watch?v=bBIu5R9UunA

4Kscore® Test (OPKO Lab, Nashville, TN) – A blood test that incorporates a panel of four kallikrein protein biomarkers (total PSA, free PSA, intact PSA, and human kallikrein-related peptidase 2) and other clinical information in an algorithm that provides a percent risk for a high-grade (Gleason score ≥ 7) cancer on biopsy.

“Men with an abnormal PSA or digital rectal examination result, and for whom an initial or repeat prostate biopsy is being considered, would benefit from a reflex 4Kscore Test.”

“The 4Kscore® Test (OPKO Lab, Nashville, TN) is a new blood test that accurately identifies the risk of aggressive prostate cancer. “

ability to discriminate between lethal and nonlethal prostate cancer, the 4Kscore Test allows us to avoid prostate biopsy in men whose cancers are better left undetected, and focus intervention on men who are most likely to benefit from it.

“A final attribute of the 4Kscore Test that is unique is the accuracy of its individualized probability prediction. The test result is a personalized positive predictive value of finding Gleason score ≥ 7 cancer on biopsy of the prostate.”

My question: Does a high PSA insure a poor reading from this test or can a high PSA exist and yet the test come back with positive results?  Kg

opkolab.com/Contact_Us.html – A Division of OPKO Health, Inc. Our Location Information: OPKO Lab: 1450 Elm Hill Pike, Nashville TN 37210 (888) 868-7522 toll free (615) 874-0410 office

SOURCE: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4444768/

Genetic Test –

SOURCE: https://www.youtube.com/watch?v=bBIu5R9UunA

3-D Color Doppler  Non-invasive. Appx $600

3T Multi-Parametric MRI BlueLaser – See http://sperlingprostatecenter.com/

2016-04-07 I contacted them via the form on their site. Questions I have for them to answer. Lillian returned my call. High PSA and family history => action needed soon. TRUS is normal procedure but SPC uses 3T MRI b/c need to know if cancer exists, so SPC uses 3T MRI to determine how aggressive the cancer cells are. Less impact b/c probe is smaller and less needles. Earlier it’s determined whether cancer exists is important. Have had patients whos’s PSA was 300 and some of them were in denial.

  • Q: Does Medicare A or B cover the costs?
    A: No. $2,500 for the MRI and consultation but -$500 via Medicare. Then the Biopsy is another $2,500 but -$500 b/c medicare. CareCredit.com is an option, 6 mo 0% interest. They do accept credit cards.
  • Q: If so, is it 100%?
    A: It picks up significant diseases. Imaging can find a lump and it not be cancer, or be cancer. A sample is required to tell for sure. Need to know the aggressiveness of those cells and the volume of the cells, all of which can be determined via a Gleason score with lab results.
  • Q: Are there any radiation risks with the 3T MRI procedure?
    A: None at all b/c magnetic.
  • Q: Do you use or promote Proton Therapy?
    A: Dr. will address this when/if needed. Proper diagnosis is my next step.
  • Q: What’s the risk of damaging other parts?
    A: Very low b/c using MRI imaging whereas TRUS has higher risk.
  • Q: I have a history of high inflammation. Is there a possibility that part or all of my high PSA reading is b/c of this?
    A: It could be but family history implies there is something else. 3T MRI can pickup inflammation in the tissue. Different sequences can be used during the exam.
  • Q: Where are you located?
    A: Located in Aventura, FL (20 minutes north of Ft Lauderdale’s FLL; moved there about 2.5 years ago, primary office is in FL) and NYC.
  • Q: When are appointments?
    A: Normal dates are Tue and Thurs. April 20th is open, 3pm – 11pm. Then May 5, 10, 12.
  • Q: Referrals available?
    A: She’ll send me some via email. Update 2016 June 15: I have not received anything from them.  Kg
  • Q: Do you have cases where high PSA but with no cancer found?
    A: It can happen. There have been a few cases. Some high PSA have ACEP cell which are atypical cells. It’s a pre-cancer cell so the patient is followed up on frequently.

On a hopeful note, this from the Sperling site: the average middle-aged man has about a 3% chance of dying from prostate cancer if he is never screened”

Positron emission tomography (PET) – by itself demonstrates high sensitivity for prostate cancer detection but nonspecific uptake in benign lesions limits its diagnostic utility.

PET combined with MRI – Has recently shown promise with a sensitivity and specificity for CaP detection in lesions >5 mm being 84% and 80%, respectively, when correlated with whole mount pathology at radical prostatectomy [43]. Furthermore, semiquantitative fluoroethylcholine uptake in identified lesions is able to discriminate between Gleason >6 CaP with a specificity of 90% and a positive predictive value of 83%, which is an improvement over that of prostate biopsy results when compared to whole mount specimens. MRI interpretation is challenging, requiring considerable experience before proficiency. Currently, mp-MRI is proving an essential adjunct to supplement PSA in proper patient selection for biopsy, treatment, and surveillance.

MRSI – A number of recent MRI studies have demonstrated that the detection and characterization of prostate cancer can be improved through the addition of MRSI [16,17,18•,19,20•,21,22•,23–26,27••,28–30,31•,32], DTI [33–38], and DCE imaging to an MRI staging exam [39••,40,41••,42–44], and by performing the imaging exam at 3T  http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2804482/

mp-MRI and fusion biopsy – Used in patients with a PSA ≥ 5.2 captured 90% of upgrading from standard 12-core to targeted biopsy [11].  http://www.hindawi.com/journals/bmri/2014/465816/ (Under 2.2, bottom of 1st paragraph)  When MP-MRI targets were used to guide biopsy, cancer was found in 37–59% of cases [16–18]

TRUS (Transrectal ultrasound) – The resolution of TRUS is generally insufficient to identify areas suspicious for tumor. An extended sextant 12-core TRUS biopsy will detect cancer in about a quarter of patients [12].TRUS guided biopsy of the prostate currently remains the gold standard for tissue diagnosis but itself has limitations

C-scan and Bone Scan – Dr. Anthony D’Amico is chief of radiation oncology at Brigham and Women’s Hospital in Boston. He said the study showed that men with high-risk prostate cancer weren’t routinely screened with a bone scan and a C-scan of the pelvis, which would detect metastatic cancer. This may account for the rise in metastatic cancer among high-risk patients before the 2012 screening recommendation, he added.

“If you have high-risk prostate cancer, make sure your doctor orders a bone scan and a C-scan of the pelvis to rule out the possibility of metastatic disease, which is almost always lethal,” he said.

Read more: Number of Advanced Prostate Cancer Cases Soars

Cell Search –  It is by a subsidiary of Johnson and Johnson.  To get this test, you have to be suspected of having metastatic disease. However, you can get it in Greece much easier!

Biopsy – “US Food and Drug Administration’s original decision to approve routine PSA screening was based on a single study that showed it could detect just 3.8% of prostate cancers” SOURCE: http://anhinternational.org/2012/09/05/anh-intl-feature-documentary-on-prostate-cancer-essential-viewing-for-all-men-over-40/

 

Prostate Cancer Detection

5 thoughts on “Prostate Cancer Detection

  • 2016/07/11 at 12:33 pm
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    PSA testing can be more harmful than helpful according to this USPSTF Assessment:

    “Although the precise, long-term effect of PSA screening on prostate cancer–specific mortality remains uncertain, existing studies adequately demonstrate that the reduction in prostate cancer mortality after 10 to 14 years is, at most, very small, even for men in what seems to be the optimal age range of 55 to 69 years. There is no apparent reduction in all-cause mortality. In contrast, the harms associated with the diagnosis and treatment of screen-detected cancer are common, occur early, often persist, and include a small but real risk for premature death. Many more men in a screened population will experience the harms of screening and treatment of screen-detected disease than will experience the benefit. The inevitability of overdiagnosis and overtreatment of prostate cancer as a result of screening means that many men will experience the adverse effects of diagnosis and treatment of a disease that would have remained asymptomatic throughout their lives. Assessing the balance of benefits and harms requires weighing a moderate to high probability of early and persistent harm from treatment against the very low probability of preventing a death from prostate cancer in the long term.
    The USPSTF concludes that there is moderate certainty that the benefits of PSA-based screening for prostate cancer do not outweigh the harms.”

    SOURCE: http://www.uspreventiveservicestaskforce.org/Page/Document/RecommendationStatementFinal/prostate-cancer-screening

    Reply
  • 2016/08/08 at 4:41 pm
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    I have found that doctors are very quick to recommend a biopsy and not mention non-invasive testing methods. If I ask about them, the doctors tend to brush the issue aside initially. If I continue asking little discussion comes forward. Only after turning down the suggestion for surgical biopsy, going home and waiting a few days or weeks, only THEN will they acknowledge other testing methods. Maybe the biopsy is more profitable? I am left to guess as to WHY they prefer biopsy but I do know that it’s the first and usually only option offered if a high PSA is detected.

    Additional testing for prostate cancer, and other cancers as well, can be found at :
    https://www.ihealthtube.com/video/these-tests-detect-cancer-earlier-why-arent-they-more-common

    Kurt Gross

    Reply
  • 2016/08/18 at 2:59 pm
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    My urologist wanted to deal with my PSA of 28 with a biopsy. I don’t like the risks and asked for other options. None were offered at the time I asked. I declined his recommendation, went home and went online looking for alternative ways to detect cancer.

    I’ve found 6 other tests, some are blood tests, some urine, that can be done. It’s important to note that none of these options can tell positive or negative results with certainty but neither can the biopsy either.

    A few weeks later the nurse at the urologist’s office called to warn me that I should get the biopsy. I told her no, that I’d learned of other options. She said she’d ask the urologist about it and get back with me. Later she called to tell me about a blood test called Apifiny.

    I told her I’d look into that, which I am currently doing. Meanwhile, I wonder why this was not offered first. I’m left to guess. Maybe it’s because the urologist does surgery for a living and that’s the first and only option offered?

    I’ve learned that a patient must realize that they are the best adviser on their side, not the doctor, no one else but themselves. Sad really that we can no longer rely on the doctor for the best advise. Everyone seems to either have a motive to direct patients into a biased option or they just don’t know about other options because they haven’t bothered to open their minds to alternative treatments.

    Kurt

    Reply

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